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Title: Role of Capsaicin in Oxidative Stress and Cancer
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Pancreatic cancer is an aggressive malignancy with poor overall prognosis. In: Srivastava S. (eds) Role of Capsaicin in Oxidative Stress and Cancer. Diet and Cancer, vol 3. Springer, Dordrecht.

Pancreatic cancer is an aggressive malignancy with poor overall prognosis. As a result, there is a crucial need to identify and develop effective strategies for treatment.

A novel role of capsaicin was also demonstrated in mediating oxidative stress. stress and apoptosis in cancer cells. 2 Role of Capsaicin in Pancreatic Cancer. Generation of Reactive Oxygen Species by Capsaicin. Capsaicin was found to inhibit Trx, causing the dissociation of the Trx-ASK1. Chapter 8. Oxidative Stress by Capsaicin in Cancer. Kartick C. Pramanik, Palika Datta, and Sanjay K. Srivastava. K. C. Pramanik, P. Datta, S. Srivastava, P. in Pancreatic Cancer Cells. Pancreas cancer, also called pancreatic cancer, occurs when cancer cells form one or more tumors in the tissues of the pancreas. Currently, pancreatic cancer is the deadliest of all solid malignancies and the fourth leading cause of cancer-related mortality in the United States (Li et al. 2010). It is more common in the elderly than in younger people, with less than 20 % of patients having localized and potentially curable tumors.

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in th. .

This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53. activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival.

of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others.

Role of Oxidative Stress in Chronic Diseases PDF Role of Oxidative Stress in Chronic Diseases PDF Free Download Role of Oxidative Stress in Chronic Diseases PDF Ebook.

Sanjay K.

Capsaicin treatment generates oxidative stress in vivo in pancreatic tumors by reducing antioxidants. Tumors from control and . mg/kg (5days/week for 6 weeks) capsaicin treated mice were analyzed for (A) SOD enzymatic activity and (B) GSSG and GSH levels

Capsaicin treatment generates oxidative stress in vivo in pancreatic tumors by reducing antioxidants. mg/kg (5days/week for 6 weeks) capsaicin treated mice were analyzed for (A) SOD enzymatic activity and (B) GSSG and GSH levels. Results are expressed as mean ± SD (n 3) of three independent tumors.

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Sanjay K. Srivastava | 2013 | ISBN: 9400763166 | English | IX, 178 pages | PDF | 5 MB
Series: Diet and Cancer (v. 3)
Thoroughly reviews the preventive and therapeutic effects of capsaicin in melanoma, pancreatic cancer, colon cancer, breast cancer, lung cancer, multiple myeloma and others
This book describes the mechanism of the anti-cancer effects of capsaicin including the involvement of cytochrome P-450 in the bioactivation; identification of mitochondria as the key target site for oxidative stress; involvement of mitochondrial respiratory chain in the production of ROS; prevention of chemically-induced carcinogenesis, discussion on TRPV-1 receptor mediated or independent anti-cancer effects; identification of p53 activation as a possible mechanism; involvement of Cox-2 in apoptosis, suppression of transcription factors such as NF-kB and STAT-3; inhibition of cell survival pathways including PI3K/Akt and the involvement of intrinsic mitochondrial cell death pathway.
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Role of Capsaicin in Oxidative Stress and Cancer FreeCourseWeb